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gene expression in osteoblasts • vitamin D • animal models of bone disease • bone fracture repair
My research program aims to identify, characterize and validate targets for pharmacological intervention and the development of rational, effective novel therapeutics for bone regenerative medicine. My team uses an integrated approach with biochemistry, molecular/cell biology, mouse molecular genetics and preclinical science to cover the full bench-to-bedside spectrum: target identification and characterization, high-throughput screening of small molecules for drug development, and validation of lead compounds. With surgeon colleagues, we are preparing a clinical trial to test the efficacy of 24,25-dihydroxyvitamin D to improve osteotomy healing.
Addison, W.N., M. Pellicelli, and R. St-Arnaud. 2019. Dephosphorylation of the transcriptional cofactor NACA by the PP1A phosphatase enhances cJUN transcriptional activity and osteoblast differentiation. J. Biol. Chem. 294: 8184-8196. PMID: 30948508.
Martineau, C., R.P. Naja, A. Husseini, B. Hamade, M. Kaufmann, O. Akhouayri, A. Arabian, G. Jones, and R. St-Arnaud. 2018. Optimal bone fracture repair requires 24R,25-dihydroxyvitamin D3 and its effector molecule FAM57B2. J. Clin. Invest. 128: 3546-3557. PMID: 30010626.
Pellicelli, M., H. Hariri, J.A. Miller, and R. St-Arnaud. 2018. Lrp6 is a target of the PTH-activated ɑNAC transcriptional coregulator. Biochim. Biophys. Acta 1861: 61-71. PMID: 29413898.
Hekmatnejad, B., V.W.C. Yu, W. Addison, V. Mandic, M. Pellicelli, A. Arabian, and R. St-Arnaud. 2017. FIAT deletion increases bone mass but does not prevent high-fat-diet-induced metabolic complications. Endocrinology 158: 264-276. PMID: 27906582.
Pellicelli, M., J.A. Miller, A. Arabian, C. Gauthier, O. Akhouayri, J.Y. Wu, H.M. Kronenberg, and R. St-Arnaud. 2014. The PTH-Gɑs-PKA cascade controls ɑNAC localization to regulate bone mass. Mol. Cell. Biol. 34: 1622-1633. PMID: 24550008.