null Salvatore Carbonetto, PhD

Honorary Investigator, RI-MUHC

Brain Repair and Integrative Neuroscience (BRaIN) Program

Centre for Translational Biology



cell adhesion molecules • synapse formation and plasticity • muscular dystrophy • autism

Research Focus

Salvatore Carbonetto received an Honorary Investigator appointment to the Research Institute of the McGill University Health Centre (RI-MUHC) in 2021. This appointment honours his distinguished contributions as a professor, researcher and leader at McGill University and the RI-MUHC and his numerous scientific contributions to the field of neuroscience. Focused on synapses and their essential role in information processing, memory storage and virtually all other brain functions, his work resulted in the discovery of dystroglycan, molecular/functional characterization of the extracellular matrix, and identification of pathways involved in synapse formation and muscular dystrophy. He hascontributed to the understanding of the genetics of neurodevelopmental disorders, including autism spectrum disorders. A former axis leader in neuroscience, his commitment to training and service to the wider RI-MUHC research community serve as an example and inspiration for all members.

Selected Publications

Click on Pubmed to see my current publications list

  • Pribiag H., Peng H., Shah W., Stellwagen D. and Carbonetto S. Activity-dependent regulation of dystroglycan is necessary for homeostatic synaptic plasticity at GABAergic synapses. Submitted.

  • Peng H, Shah WA, Holland PC and Carbonetto S. (2013) Integrins regulate centrosome integrity and astrocyte polarization. Devel. Neurobiol. 73:333-353. PMID: 22949126.

  • Gauthier J, Champagne al. (2010) De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia. Proc, Natl. Acad. Sci. 107:7863-8. PMID: 20385823.

  • Gauthier J, Siddiqui TJ, et al. (2011) Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia. Hum. Genet. 130:563-73.

  • Zhan Y, Melian NY, Pantoja M, Haines N, Ruohola-Baker H, Bourque CW, Rao Y, and Carbonetto S. (2010) Dystroglycan and Mitochondrial Ribosomal Protein L34 Regulate Differentiation in the Drosophila Eye. PLoS ONE 5:10488