RI-MUHC scientist leads study linking bacterial infection with moderate but significant increase in the risk of Alzheimer’s disease in older adults
Source: McGill Newsroom
December 20, 2023
A common stomach bacteria found in two thirds of the world population may be linked to a higher risk of Alzheimer’s disease, new research suggests.
The study, published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association, investigated whether a clinically apparent Helicobacter pylori (H. pylori) infection increased the risk of Alzheimer's disease in people aged 50 and older. The prevalent infection can trigger indigestion, gastritis, ulcers, and even stomach cancer.
A team of McGill University researchers analyzed health data of over 4 million people in the United Kingdom aged 50 and above between 1988 and 2019. It found that people with symptomatic H. pylori infection had an 11% higher risk of developing Alzheimer's disease, the most common type of dementia. While the cause of Alzheimer’s disease is multifaceted, the findings build upon a growing body of evidence on the potential role of infections, particularly H. Pylori, in its development. The study opens avenues for future research, particularly exploring whether eradicating this bacterium could effectively prevent Alzheimer's disease in some people.
Alzheimer’s disease affects millions of people globally, with numbers expected to rise sharply as demographics shift, say researchers. “Given the global ageing population, dementia numbers are expected to triple in the next 40 years. However, there remains a lack of effective treatment options for this disease,” said Dr. Paul Brassard, the study’s senior author, a scientist in the Infectious Diseases and Immunity in Global Health Program at the Research Institute of the McGill University Health Centre (RI-MUHC) and a professor in McGill’s Department of Medicine.
“We hope the findings from this investigation will provide insight on the potential role of H. pylori in dementia in order to inform the development of prevention strategies, such as individualized eradication programs, to reduce infections at the population level,” said Dr. Brassard, who is also a public health and preventive medicine physician at the McGill University Health Centre.
About the study
Clinically apparent Helicobacter pylori infection and the risk of incident Alzheimer’s disease: a population-based nested case-control study by Antonios Douros et al. was published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association. The study was funded by a project grant from the Canadian Institutes of Health Research (CIHR).
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