RI-MUHC Annual Report

RI-MUHC ANNUAL REPORT 2021

YEAR IN REVIEW

INJURY REPAIR RECOVERY (IRR) PROGRAM

RESEARCH HIGHLIGHTS

Patients’ perspectives: “When will I recover?”

To patients, the meaning of recovery goes beyond traditional clinical parameters commonly assessed in surgical research. Findings by Drs. Julio F. Fiore Junior, Liane Feldman and colleagues support consideration of an interplay of physical, psychological and social factors in surgeon-patient discussions about postoperative recovery. (JAMA Surgery)

“Zombie” cells breakthrough recognized by Arthritis Society

Research by postdoctoral fellow Hosni Cherif made the Arthritis Society’s Top 10 Breakthroughs list in 2020. Studying spine degeneration, he found that RG-7112, a synthetic drug, and o-Vanillin, a natural compound, triggered changes that helped grow new, healthy cells while also killing senescent or “zombie” cells. These findings could lead to new drugs for back pain.

Left to right: Drs. Julio F. Fiore Junior and Liane Feldman, co-principal investigators of a study on patients’ perspectives; postdoctoral fellow Hosni Cherif, PhD, and his research supervisor, Dr. Lisbet Haglund, recognized by the Arthritis Society

Winners of the 2021 McGill Clinical Innovation Competition

The Remote Optical team, first-place winner of the Marika Zelenka Roy Innovation Prize, included three IRR Program trainees, as did NURA Medical, which took second place and also won the Bereskin and Parr Innovation Prize. Both teams are now members of the Clinical Innovation Platform at the RI-MUHC.

Left to right: Remote Optical co-founders Oliver Wu Martinez, Dr. Leonard Levin (investigator in the BRaIN Program), Angela Wong and Jeremy Zwaig; NURA Medical leadership team members Sofia Addab, Georgia Powell and Jean-Gabriel Lacombe

Selected IRR Program news links

The Clinical Innovation Platform at the RI-MUHC announced the residency of its first member company, AltPAP Innovation, in 2021. Pictured here: Tatiana Ruiz (left) and Patricia McClurg, both of AltPAP innovation, and the ScubaPAP oxygenation device.

SELECTED PUBLICATIONS

Alan N.G. Barkun, Myriam Martel, Ian L. Epstein, Pierre Hallé, R. J. Hilsden, Paul D. James, Alaa Rostom, Michael Sai Lai Sey, Harminder Singh, Richard A. Sultanian, Jennifer J. Telford, Daniel von Renteln. The Bowel CLEANsing National Initiative: A Low-Volume Same-Day Polyethylene Glycol (PEG) Preparation vs Low-Volume Split-Dose PEG With Bisacodyl or High-Volume Split-Dose PEG Preparations-A Randomized Controlled Trial. The American Journal of Gastroenterology 115(12): 2068-2076, 2020. doi: 10.14309/ajg.0000000000000760.

Omar Kherad, Sophie Restellini, Majid Abdulrahman Almadi, Lisa L. Strate, Charles Ménard, Myriam Martel, Ira Roshan-Afshar, Mohamad Seyed Sadr, Alan N.G. Barkun. Systematic review with meta-analysis: limited benefits from early colonoscopy in acute lower gastrointestinal bleeding. Alimentary Pharmacology and Therapeutics 52(5): 774-788, 2020. doi: 10.1111/apt.15925.

Franco M. Carli. Prehabilitation for the Anesthesiologist. Anesthesiology. 133(3): 645-652, 2020. doi: 10.1097/ALN.0000000000003331.

Teodora Cristiana Dumitra, Olivia Ganescu, Richard Hu, Julio F. Fiore Jr., Pepa A. Kaneva, Nancy E. Mayo, Lawrence F.Lee, Alexander Sender Liberman, Prosanto K. Chaudhury, Lorenzo Ferri, Liane S. Feldman. Association between Patient Activation and Health Care Utilization after Thoracic and Abdominal Surgery. JAMA Surgery 156(1), 2021. doi: 10.1001/jamasurg.2020.5002.

Saba Balvardi, Nicolò Pecorelli, Tanya Castelino, Petru Niculiseanu, Mohsen Alhashemi, Alexander Sender Liberman, Patrick Charlebois, Barry L. Stein, Franco M. Carli, Nancy E. Mayo, Liane S. Feldman, Julio F. Fiore Jr. Impact of Facilitation of Early Mobilization on Postoperative Pulmonary Outcomes After Colorectal Surgery: A Randomized Controlled Trial. Annals of Surgery 273(5): 868-875, 2021. doi: 10.1097/SLA.0000000000003919.

Marc Olivier Martel, Robert R. Edwards, Robert N. Jamison. The relative contribution of pain and psychological factors to opioid misuse: A 6-month observational study. American Psychologist 75(6): 772-783, 2020. doi: 10.1037/amp0000632.

Francis McEachern, E. J. Harvey, Geraldine Merle. Emerging Technologies for the Electrochemical Detection of Bacteria. Biotechnology Journal 15(9), 2020. doi: 10.1002/biot.202000140.

Faegheh Ghanbari, Sylvie Mader, Anie Philip. Cholesterol as an Endogenous Ligand of ERRα Promotes ERRα-Mediated Cellular Proliferation and Metabolic Target Gene Expression in Breast Cancer Cells. Cells 9(8), 2020. doi: 10.3390/cells9081765.

Damian Rauch, Marie Ève Robinson, Cristian Seiltgens, Vernon Reid Sutton, Brendan H.L. Lee, Francis H. Glorieux, Frank Rauch. Assessment of longitudinal bone growth in osteogenesis imperfecta using metacarpophalangeal pattern profiles. Bone 140: 115547, 2020. doi: 10.1016/j.bone.2020.115547.

Hadla Hariri, Martin Pellicelli, René A. St.-Arnaud. Nfil3, a target of the NACA transcriptional coregulator, affects osteoblast and osteocyte gene expression differentially. Bone 141: 115624, 2020. doi: 10.1016/j.bone.2020.115624.

Maximilian Rummler, Fani Ziouti, Alice L. Bouchard, Andreas Brandl, Georg N. Duda, B. Bogen, Andreas Beilhack, Maureen E. Lynch, Franziska Jundt, Bettina M. Willie. Mechanical loading prevents bone destruction and exerts anti-tumor effects in the MOPC315.BM.Luc model of myeloma bone disease. Acta Biomaterialia 119: 247-258, 2021. doi: 10.1016/j.actbio.2020.10.041.