growth • gene regulation • obesity • cancer • endocrine disruptors
My research focuses on two questions: (1) How is expression of the human growth hormone receptor regulated during childhood growth, obesity and cancer; and (2) what are the possible endocrine disruptor effects of certain environmental chemical contaminants (brominated flame retardants) on the human reproductive system during development and in the adult.
Kenth, G.*, Puzhko, S.+ and Goodyer, C.G. Human growth hormone receptor gene expression is regulated by Gfi-1/Gfi-1b and GAGA cis-elements. Mol Cell Endocrinol 335: 135-147, 2011. PMID: 21238539.
Erman, A.*, Wabitsch, M. and Goodyer, C.G. Human growth hormone receptor (GHR) expression in obesity: II. Regulation of the human GHR gene by obesity-related factors. Int J Obesity 35: 1520-1529, 2011. PMID: 21386799.
Rawn, D.F.K., Gaertner, D.W., Weber, D., Curran, I.H.A., Cooke G.M. and Goodyer, C.G. Hexabromocyclododecane concentrations in Canadian human fetal liver and placental tissues. Science of the Total Environment 468-9C: 622-629, 2014. PMID: 24061053.
Elzein, S.* and Goodyer, C.G. Regulation of human growth hormone receptor expression by microRNAs. Mol Endocrinol 28: 1448-1459, 2014. PMID: 25073105.
Poon, S., Wade, M.W., Aleksa, K., Rawn, D.F.K., Carnevale, A., Gaertner, D.W., Sadler, A., Breton, F., Koren, G., Ernest, S.R., Lalancette, C, Robaire, B., Hales, B.F. and Goodyer, C.G. Hair as a biomarker of exposure to polybrominated diphenyl ethers (PBDEs). Environ Sci Technol 48: 14650-14658, 2014. PMID: 25387207.