Fil d'Ariane

null Laurence Chapuy, M.D., Ph. D.

Mots-clés


inflammatory bowel disease • mucosal immunology • innate immunity • mononuclear phagocytes • fibrosis

Aire de recherche


Mes recherches se concentrent sur les mécanismes immunologiques sous-jacents aux maladies inflammatoires de l’intestin. J’étudie le rôle des cellules immunitaires innées, appelées phagocytes mononucléaires, dans les tissus inflammatoires ou cicatriciels des patients atteints de colite ulcéreuse ou de la maladie de Crohn.

Publications choisies


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  • Chapuy, L., Bsat, M., Sarkizova, S., Rubio, M., Therrien, A., Wassef, E., Bouin, M., Orlicka, K., Weber, A., Hacohen, N., Villani, A.C., Sarfati, M. Two distinct colonic CD14+ subsets characterized by single-cell RNA profiling in Crohn's disease. Mucosal Immunol, 12(3):703-719. PMID: 30670762.

  • Chapuy, L., Bsat, M., Rubio, M., Harvey, F., Motta, V., Schwenter, F., Wassef, R., Richard, C., Deslandres, C., Nguyen, B.N., Soucy, G., Hacohen, N., Fritz, J., Villani, A.C., Mehta, H., Sarfati, M. Transcriptomic analysis and high dimensional phenotypic mapping of mononuclear phagocytes in mesenteric lymph nodes reveal differences between ulcerative colitis and Crohn's disease. Journal of Crohn and colitis, 13;14(3):393-405. PMID: 31541232.

  • Chapuy, L., Bsat, M., Rubio, M., Sarkizova, S., Therrien, A., Bouin, M., Orlicka, K., Weber, A., Soucy, G., Villani, A.C., Sarfati, M. IL-12 and mucosal CD14+ monocyte-like cells induce IL-8 in colonic memory CD4+ T cells of patients with Ulcerative colitis but not Crohn's disease. Journal of Crohn and Colitis, 14(1):79-95. PMID: 31206576.

  • Chapuy, L., Bsat, M., Mehta, H., Rubio, M., Wakahara, K., Van, V.Q., Baba, N., Cheong, C., Yun, T.J., Panzini, B., Wassef, R., Richard, C., Tamaz, R., Soucy, G., Delespesse, G., Sarfati, M. Basophils increase in Crohn's disease and Ulcerative colitis and favor mesenteric lymph node memory Th17/Th1 response. J Allergy Clin Immunol, 134(4):978-81.e1. PMID: 24996262.

  • Bsat, M., Chapuy, L., Rubio, M., and Sarfati, M. A two-step human culture system replicates intestinal monocyte maturation cascade: Conversion of tissue-like inflammatory monocytes into macrophages. Eur J Immunol, 50(1):1676-1690. PMID: 32557554.