Mots-clés

transplantation • islet • antigen presentation • stem cells • immunity

Aire de recherche

Ma recherche porte sur les signaux libérés par les greffons transplantés qui fournissent un stimulus clé au système immunitaire. Je participe également à un grand groupe de recherche qui développe un dispositif à base de cellules souches pour inverser le diabète.

Publications choisies

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• Fouda, S Negi, O Zaremba, R Gaidar, S Paraskevas, J Tchervenkov, Discovery, synthesis, and in vitro characterization of 2,3 derivatives of 4,5,6,7-tetrahydro-benzthiophene as potent modulators of retinoic acid receptor-related orphan receptor γt, J Med Chem, 2023, Jun 8;66(11): 7355-73. doi: 10.1021/acs.jmedchem.3c00021. PMID: 37172324.

• AK Rutman, S Negi, N Saberi, K Khan, JI Tchervenkov, S Paraskevas, Extracellular vesicles from kidney allografts express miR-218-5p and alter Th17/Treg ratios, Front Immunol, 2022, Feb 23; 13: article 784374. PMID: 35281056.

• AK Rutman, S Negi, M Gasparrini, *CP Hasilo, J Tchervenkov and S Paraskevas, Immune response to extracellular vesicles from human islets of Langerhans in patients with Type 1 diabetes, Endocrinology, 2018 Nov 1;159(11):3834-3847. PMID: 30307543.

• SA Fernandez, L Danielczak, G Gauvin-Rossignol, C Hasilo, A Bégin-Drolet, J Ruel, S Paraskevas, RL Leask, CA Hoesli, An in vitro perfused macroencapsulation device to study hemocompatibility and survival of islet-like cell clusters, Front Bioeng Biotechnol, 2021, May 28;9:674125. PMID: 34124024.

• TB McGregor, A Sener, K Yetzer, C Gillrie, S Paraskevas, The impact of COVID-19 on the Canadian Kidney Paired Donation program: an opportunity for universal implementation of kidney shipping. Can J Surg, 2020 Oct 01; 63(5): E451-3. doi: 10.1503/cjs.012620.