Breadcrumb

null Dae-Kyum Kim, PhD

Junior Scientist, RI-MUHC, Glen site

Cancer Research Program

Centre for Translational Biology

 

Keywords

functional genomics • systems biology • bioinformatics • gastro-esophageal cancer • drug resistance • extracellular vesicle • autophagy

Research Focus

Throughout my career, I have focused on generating and integrating functional genomics data to propose novel hypotheses for experimental validation or new clinical biomarkers. During my undergraduate training, I developed a sequence comparison method to classify proteins by structure. My PhD research involved high-throughput screening methods like mass spectrometry and RNA-seq to study extracellular vesicles, leading to the creation of the EVpedia database. In my postdoctoral work, I explored protein–protein interactions to understand human disease mechanisms, contributing to the Human Reference Interactome (HuRI) and identifying interactions between SARS-CoV-2 and host proteins. Now, as a principal investigator, I aim to translate functional genomics tools to precision medicine, focusing on novel drug combinations to combat therapeutic resistance in gastro-esophageal cancer. My experience in leading large teams and efficient administrative skills will support my efforts to identify new biomarkers and therapeutic targets.

Selected Publications

Click on Pubmed to see my current publications list

  • Kim DK*, WellerB*, Lin CW*, Sheykhkarimli D*, Knapp JJ*, Dugied G*, …, Demeret C#, Vidal M#, Calderwood MA#, Roth FP#, Falter-Braun P#. A proteome-scale map of the SARS-CoV-2 human contactome. Nat Biotechnol. 2023 Jan;41(1):140-149.

  • Luck K*, Kim DK*, Lambourne L*, Spirohn K*, …, Tavernier J#, Hill DE#, Vidal M#, Roth FP#, Calderwood MA#. A reference map of the human binary protein interactome. Nature. 2020 Apr;580(7803):402–8. PMCID: PMC7169983.

  • Kim DK*, Lee J*, …, Gho YS. EVpedia: A community web portal for extracellular vesicles research. Bioinformatics. 2015 Mar 15;31(6):933–9. PMCID: PMC4375401.

  • Lim HJ*, Yoon H*, Kim H*, Kang YW, Kim JE, Kim OY, Lee EY, Twizere JC, Rak J#, Kim DK#. Extracellular vesicle proteomes shed light on the evolutionary, interactive, and functional divergence of their biogenesis mechanisms. Front Cell Dev Biol. 2021 Oct 1;9:734950. PMCID: PMC8517337.

  • Yu J*, Sane S*, Kim JE*, Yun S*, Kim HJ, Jo KB, Wright JP, Khoshdoozmasouleh N, Lee K, Oh HT, Thiel K, Parvin A, Williams X, Hannon C, Lee H#, Kim DK#. Biogenesis and delivery of extracellular vesicles: harnessing the power of EVs for diagnostics and therapeutics. Frontiers in Molecular Biosciences. 2024 Jan 3:10:1330400. (Cited 1 time; PMID: 38234582; PMCID: PMC10791869).