Ivan Litvinov, MD, PhD, FRCPC
Basal cell carcinoma • cutaneous T-cell lymphoma • gene expression profiling • oncolytic viruses • cancer epidemiology
My laboratory studies the genetic bases of cutaneous T-cell lymphoma (CTCL) carcinogenesis and cancer progression with a focus on application and translation of the newly discovered molecular knowledge into clinical practice. We are elucidating how hypopigmented mycosis fungoides (MF), which primarily affects adolescents and young adults, differs from classic patch/plaque MF, which affects older individuals. We are actively developing a novel diagnostic/prognostic molecular test for CTCL patients, which would help distinguish this disease from its benign mimickers and help identify certain patients (approximately 20%) who are at risk of disease progression. We are also studying the expression and function of cancer testis (CT) and embryonic stem cell (ESC) genes in CTCL. In addition, working with our collaborators, we are investigating novel treatment approaches using oncolytic viruses for CTCL, basal cell and squamous cell carcinomas. Another branch of research in the lab is to study the geographic distribution of human cancers in Canada.
Elena Netchiporouk, Jennifer Gantchev, Matthew Tsang, Philippe Thibault, Andrew K. Watters, John-Douglas Matthew Hughes, Feras M. Ghazawi, Anders Woetmann, Niels Ødum, Denis Sasseville and Ivan V. Litvinov. “Analysis of CTCL cell lines reveals important differences between mycosis fungoides/sézary syndrome vs. HTLV-1+ leukemic cell lines.” Oncotarget 8(56):95981-95998. (Nov 2017). PMID: 29221181.
Feras M. Ghazawi, Elena Netchiporouk, Elham Rahme, Matthew Tsang, Linda Moreau, Steven Glassman, Nathalie Provost, Martin Gilbert, Sara-Elizabeth Jean, Kevin Pehr, Denis Sasseville, Ivan V. Litvinov “Comprehensive Analysis of Cutaneous T-Cell Lymphoma (CTCL) Incidence and Mortality in Canada Reveals Changing Trends and Geographic Clustering for this Malignancy.” Cancer 123 (18):3550-3567. (Sept 2017).
Ivan V. Litvinov, Michael Tetzlaff, Philippe Thibault, Pamela Gangar, Linda Moreau, Andrew K. Watters, Elena Netchiporouk, Kevin Pehr, Victor Prieto, Elham Rahme, Nahtalie Provost, Martin Gilbert, Denis Sasseville, Madeleine Duvic ”Gene expression analysis in Cutaneous T-Cell Lymphomas (CTCL) highlights disease heterogeneity and potential diagnostic and prognostic indicators.” OncoImmunology 6(5): e1306618.1-12. (Mar 2017). PMID: 28638728.
Ivan V. Litvinov, Brendan Cordeiro, Yuanshen Huang, Hanieh Zargham, Kevin Pehr, Marc-Andre Doré, Martin Gilbert, Youwen Zhou, Thomas S. Kupper and Denis Sasseville. ”Ectopic expression of cancer testis antigens in Cutaneous T-Cell Lymphoma (CTCL) patients.” Clin. Cancer Res., 20(14):3799-808 doi: 10.1158/1078-0432.CCR-14-0307. (July 2014). PMID: 24850846.
Ivan V. Litvinov, Elena Netchiporouk, Brendan Cordeiro, Marc-Andre Doré, Linda Moreau, Kevin Pehr, Martin Gilbert, Youwen Zhou, Denis Sasseville and Thomas S. Kupper. “The use of transcriptional profiling to improve personalized diagnosis and management of Cutaneous T-Cell Lymphoma (CTCL).” Clin. Cancer Res., 21(12); 2820–9. 2015; doi: 10.1158/1078-0432.CCR-14-3322. (June 2015). PMID: 25779945.