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George Zogopoulos, MD, PhD, FRCSC, FACS

Scientist, RI-MUHC, Glen site

Cancer Research Program

Assistant Professor of Surgery

 

Keywords


Pancreatic cancer • hereditary cancer • hepato-pancreato-biliary surgery • translational research

Research Focus


My research focuses on developing a translational research program in pancreatic cancer. My work focuses on elucidating the genetics of pancreatic cancer, investigating the therapeutic sensitivities of subsets of pancreatic cancer, translating these findings to clinical care, developing genetic and clinical screening strategies for individuals at a high life-time risk for pancreatic cancer, and establishing surgical treatment strategies for locally advanced pancreatic cancer. To pursue these research goals, I established a prospective clinic-based research registry for patients with pancreatic cancer and related conditions (the Quebec Pancreas Cancer Study), with an accompanying biospecimen repository and a patient-derived pancreatic cancer mouse xenograft program. My clinical interests include the surgical treatment of pancreatic, biliary and hepatic malignancies as well as abdominal organ transplantation.

Selected Publications


Click on Pubmed to see my current publications list

  • Zanke B.W., Greenwood C.M., Rangrej J., Kustra R., Tenesa A., Farrington S.M., Prendergast J., Olschwang S., Chiang T., Crowdy E., Ferretti V., Laflamme P., Sundararajan S., Roumy S., Olivier J.F., Robidoux F., Sladek R., Montpetit A., Campbell P., Bezieau S., O'Shea A.M., Zogopoulos G., Cotterchio M., Newcomb P., McLaughlin J., Younghusband B., Green R., Green J., Porteous M.E., Campbell H., Blanche H., Sahbatou M., Tubacher E., Bonaiti-Pellié C., Buecher B., Riboli E., Kury S., Chanock S.J., Potter J., Thomas G., Gallinger S., Hudson T.J., Dunlop M.G. A Colorectal Cancer Susceptibility Locus on Chromosome 8q24 Identified by a Genome-Wide Association Scan. Nature Genet. 39(8):989-94, 2007. PMID: 17415588

  • Zogopoulos G., Ha K.C., Naqib F., Moore S., Kim H., Montpetit A., Robidoux F., Laflamme P., Cotterchio M., Greenwood C., Scherer S.W., Zanke B., Hudson T.J., Bader G.D., Gallinger S. Germ-line DNA copy number variation frequencies in a large North American population. Hum Genet. 122(3-4):345-53, 2007. PMID: 1763801

  • Zogopoulos G., Rothenmund H., Eppel A., Ash C., Akbari M.R., Hedley D., Narod S.A., Gallinger S. The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer. Hum. Genet. 121(5):635-7, 2007. PMID: 17638019

  • Zogopoulos G., Jorgensen C., Bacani J., Montpetit, A, Lepage P., Ferretti V., Chad L., Selvarajah S., Zanke B., Hudson T., Pawson T., Gallinger S. Germline EPHB2 Receptor Variants in Familial Colorectal Cancer. Plos ONE 6;3(8):e2885, 2008. PMID: 18682749

  • Holter S., Pollett A., Zogopoulos G., Kim H., Schwenter F., Asai K., Gallinger S., Clendenning M., Steinbach G., Jacobson A., Boycott K.M. Hepatic Adenomas Caused by Somatic TCF1 Mutations in Children with Biallelic Mismatch Repair Gene Mutations. Gastroenterology 140(2):735-6, 2011. PMID: 21182953