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Pierre Lachapelle, PhD

Senior Scientist, RI-MUHC, Glen site

Child Health and Human Development Program

Professor, Department of Ophthalmology, Division of Ophtalmology, Faculty of Medicine, McGill University

 

Keywords


ophthalmology • electroretinography • electrophysiology • development • retinopathy

Research Focus


My research focuses on developing models (human and animal) aimed at improving our understanding of normal and pathological visual function, from the retina to the visual cortex. My laboratory is also involved in characterizing animal models of human retinal diseases such as retinopathy of prematurity, age-related macular degeneration, and retinitis pigmentosa, for example, with the goal of further elucidating the pathogenesis of these retinopathies and exploring new therapeutic strategies with which to eradicate them.

Selected Publications


  • Jung S, Polosa A, Lachapelle P, Wintermark P. Visual Impairments Following Term Neonatal Encephalopathy: Do Retinal Impairments Also Play a Role? Invest Ophthalmol Vis Sci. 2015 Aug 1;56(9):5182-93. doi: 10.1167/iovs.15-16407. PMID: 26244294.

  • Mathieu Gauvin, Jean-Marc Lina, and Pierre Lachapelle, "Advance in ERG Analysis: From Peak Time and Amplitude to Frequency, Power, and Energy," BioMed Research International, vol. 2014, Article ID 246096, 11 pages, 2014. doi:10.1155/2014/246096. PMID: 25061605.

  • Garon ML, Dorfman AL, Racine J, Koenekoop RK, Little JM, Lachapelle P. Estimating ON and OFF contributions to the photopic hill: normative data and clinical applications. Doc Ophthalmol. 2014 Aug;129(1):9-16. PMID: 24894580.

  • Racine J, Joly S, Lachapelle P. Longitudinal assessment of retinal structure and function reveals a rod-cone degeneration in a guinea pig model initially presented as night blind. Doc Ophthalmol 123(1):1-19, 2011. PMID: 21656001.

  • Dorfman AL, Cuenca N, Pinilla I, Chemtob S, Lachapelle P. Immunohistochemical evidence of synaptic retraction, cytoarchitectural remodeling and cell death in the inner retina of the rat model of OIR. Investigative Ophthalmology and Visual Science 52:1693-1708, 2011. PMID: 21071736.