Breadcrumb

null Simon Ducharme, MD, M.Sc.

Associate Investigator, RI-MUHC

Brain Repair and Integrative Neuroscience (BRaIN) Program

Montreal Neurological Institute

 

Keywords

precision psychiatry • neuropsychiatry • frontotemporal dementia • biomarkers

Research Focus

My research focuses on finding new diagnostic biomarkers and treatments for neuropsychiatric disorders, with a particular focus on frontotemporal dementia. I am the scientific director of the Centre for Precision Psychiatry at the MUHC, a large research database that aims to use artificial intelligence techniques to identify better treatments for psychiatric disorders.

Selected Publications

Click on Pubmed to see my current publications list

  • Ducharme S, Dols A, Laforce Jr R, Devenney E, Kumfor F, van den Stock J, Dallaire-Théroux C, Seelaar H, Gossink F, Vijverberg E, Huey E, Vandenbuicke M, Masellis M, Trieu C, Onyike C, Caramelli P, de Souza L, Santillo A, Landqvist Waldö M, Landin-Romero R, Piguet O, Kelso W, Eratne D, Velakouli D, Ikeda M, Perry D, Pressman P, Boeve B, Vandenberghe, R, Mendez M, Azuar C, Levy R, Le Ber I, Baez S, Lerner A, Ellajosyula R, Pasquier F, Galimberti D, Scarpini E, van Swieten J, Hornberger M, Rosen H, Hodges J, Diehl-Schmid J, Pijnenburg Y. Recommendations to Distinguish Behavioural Variant Frontotemporal Dementia from Psychiatric Disorders. Brain. 2020 Jun 1;143(6):1632-1650. PMID: 32129844.

  • Levy JP, Bezgin G, Savard M, Pascoal TA, Finger E, Laforce R, Sonnen JA, Soucy JP, Gauthier S, Rosa-Neto P, Ducharme S. 18F-MK-6240 tau-PET in genetic frontotemporal dementia. Brain. 2022 Jun 3;145(5):1763-1772. doi: 10.1093/brain/awab392. PMID: 34664612.

  • Le Blanc G, Jetté Pomerleau V, McCarthy J, Borroni B, van Swieten J, Galimberti D, Sanchez-Valle R, LaForce R Jr, Moreno F, Synofzik M, Graff C, Masellis M, Tartaglia MC, Rowe JB, Vandenberghe R, Finger E, Tagliavini F, de Mendonça A, Santana I, Butler C, Gerhard A, Danek A, Levin J, Otto M, Frisoni G, Sorbi S, Rohrer JD, Ducharme S; Genetic Frontotemporal Dementia Initiative (GENFI). Faster Cortical Thinning and Surface Area Loss in Presymptomatic and Symptomatic C9orf72 Repeat Expansion Adult Carriers. Ann Neurol. 2020 Jul;88(1):113-122. doi: 10.1002/ana.25748. Epub 2020 May 12. PMID: 32285980.

  • Manera AL, Dadar M, Collins DL, Ducharme S; Frontotemporal Lobar Degeneration Neuroimaging Initiative (FTLDNI); Alzheimer's Disease Neuroimaging Initiative (ADNI). Ventricular features as reliable differentiators between bvFTD and other dementias. Neuroimage Clin. 2022;33:102947. doi: 10.1016/j.nicl.2022.102947. Epub 2022 Jan 22. PMID: 35134704.

  • Shafiei G, Bazinet V, Dadar M, Manera AL, Collins DL, Dagher A, Borroni B, Sanchez-Valle R, Moreno F, Laforce R, Graff C, Synofzik M, Galimberti D, Rowe JB, Masellis M, Tartaglia MC, Finger E, Vandenberghe R, de Mendonça A, Tagliavini F, Santana I, Butler C, Gerhard A, Danek A, Levin J, Otto M, Sorbi S, Jiskoot LC, Seelaar H, van Swieten JC, Rohrer JD, Misic B, Ducharme S; Frontotemporal Lobar Degeneration Neuroimaging Initiative (FTLDNI); GENetic Frontotemporal dementia Initiative (GENFI). Network structure and transcriptomic vulnerability shape atrophy in frontotemporal dementia. Brain. 2022 Feb 21:awac069. doi: 10.1093/brain/awac069. PMID: 35188955.