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angle-left Jean-François Yale, MD, FRCPC

Senior Scientist, RI-MUHC, Glen site

Metabolic Disorders and Complications Program

Professor, Department of Medicine, Division of Endocrinology and Metabolism, Faculty of Medicine, McGill University



clinical trials in diabetes • hypoglycemia • intensive management of diabetes • adherence

Research Focus

My research focuses on the rigourous assessment through large international studies of new therapies to treat type 1 and type 2 diabetes. This may involve new medications before they come to market, new strategies on how to use current therapies or the assessment of how well we are doing in using our current tools. I also have a special interest on the impact of renal disease on our therapies, on adherence to medications and on the prevention and treatment of hypoglycemia.

Selected Publications

Click on Pubmed to see my current publications list

  • Diabetes Care. 2013 Oct 29. [Epub ahead of print] Does a patient-managed insulin intensification strategy with insulin glargine and insulin glulisine provide similar glycemic control as a physician-managed strategy? Results of the START (Self-Titration with Apidra(R) to Reach Target) Study - A randomized non-inferiority trial. Harris SB, Yale JF, Berard L, Stewart J, Abbaszadeh B, Webster-Bogaert S, Gerstein HC. PMID: 24170757.

  • Diabetes Obes Metab. 2013 May;15(5):463-73. doi: 10.1111/dom.12090. Epub 2013 Mar 28. Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease. Yale JF, Bakris G, Cariou B, Yue D, David-Neto E, Xi L, Figueroa K, Wajs E, Usiskin K, Meininger G. PMID: 23464594.

  • Observational study of once-daily insulin detemir in people with type 2 diabetes aged 75 years or older: a sub-analysis of data from the Study of Once daily LeVEmir (SOLVE). Karnieli E, Baeres FM, Dzida G, Ji Q, Ligthelm R, Ross S, Svendsen AL, Yale JF; SOLVE Study Group. Drugs Aging. 2013 Mar;30(3):167-75. doi: 10.1007/s40266-013-0054-3. [PubMed - indexed for MEDLINE] PMID: 23371395.

  • Type 2 diabetes mellitus management in Canada: is it improving? Leiter LA, Berard L, Bowering CK, Cheng AY, Dawson KG, Ekoé JM, Fournier C, Goldin L, Harris SB, Lin P, Ransom T, Tan M, Teoh H, Tsuyuki RT, Whitham D, Woo V, Yale JF, Langer A. Can J Diabetes. 2013 Apr;37(2):82-9. doi: 10.1016/j.jcjd.2013.02.055. Epub 2013 Apr 23. PMID: 24070797.

  • Insulin use in elderly adults: risk of hypoglycemia and strategies for care. Ligthelm RJ, Kaiser M, Vora J, Yale JF. J Am Geriatr Soc. 2012 Aug;60(8):1564-70. doi: 10.1111/j.1532-5415.2012.04055.x. Epub 2012 Aug 6. [PubMed - indexed for MEDLINE] PMID: 22881394.